Title: Signal recognition particle-dependent membrane insertion of mouse invariant chain: a membrane-spanning protein with a cytoplasmically exposed amino terminus Document date: 1986_6_1
ID: 4sw25blb_5
Snippet: The complete sequences of human and mouse Ii chain have been determined (11, 31, 40, 42) . DNA sequence analysis shows that Ii chain contains a single stretch of hydrophobic amino acids, and this is located between residues 31 and 56. Based on this finding, it has been proposed that Ii chain spans the membrane close to the NH2 terminus and exposes the NH2 terminus on the cytoplasmic side of the membrane (11, 40, 42) . Here we provide direct exper.....
Document: The complete sequences of human and mouse Ii chain have been determined (11, 31, 40, 42) . DNA sequence analysis shows that Ii chain contains a single stretch of hydrophobic amino acids, and this is located between residues 31 and 56. Based on this finding, it has been proposed that Ii chain spans the membrane close to the NH2 terminus and exposes the NH2 terminus on the cytoplasmic side of the membrane (11, 40, 42) . Here we provide direct experimental evidence that the mouse li chain exposes its NH2 terminus on the cyto-plasmic side of ER membranes and that Ii chain is inserted into the membrane in an SRP-dependent manner.
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