Author: Yanrong Li; Ying Liao; Qiaona Niu; Feng Gu; Yingjie Sun; Chunchun Meng; Lei Tan; Cuiping Song; Xusheng Qiu; Chan Ding
Title: CHOP and IRE1a-XBP1/JNK signaling promote Newcastle Disease Virus induced apoptosis and benefit virus proliferation Document date: 2018_4_12
ID: mrpj8l3q_11
Snippet: Taken together, these data further demonstrate that CHOP promotes apoptosis via 388 down-regulation of BCL-2 and MCL-1, and helps NDV proliferation. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/300129 doi: bioRxiv preprint phospho-JNK (34.5-to 120-fold) and phospho-p38 (1.7-to 23.9-fold) at 12-24 h.p.i. 411 were detected in NDV-infected cells, both of which were almost undetectable in 412 m.....
Document: Taken together, these data further demonstrate that CHOP promotes apoptosis via 388 down-regulation of BCL-2 and MCL-1, and helps NDV proliferation. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/300129 doi: bioRxiv preprint phospho-JNK (34.5-to 120-fold) and phospho-p38 (1.7-to 23.9-fold) at 12-24 h.p.i. 411 were detected in NDV-infected cells, both of which were almost undetectable in 412 mock-infected cells. Above results reveals that NDV infection moderately activates 413 pro-survival AKT and ERK1/2, and greatly stimulates pro-apoptotic JNK and p38 414 signaling at late infection stage.
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