Selected article for: "activity modulate and virus replication"
Author: Poltronieri, Palmiro; Sun, Binlian; Mallardo, Massimo
Title: RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load
  • Document date: 2015_10_23
    • ID: 259cspey_57
    Snippet: Clearly the cell is not a passive participant in virus replication. In addition to the cellular pathways subverted by the virus for its own use there are inhibitory factors within cells which act as intracellular defences and whose presence inhibits or 'restricts' the virus. The first one, identified in retrovirus infected cells, was Fv1 which restricts ecotropic murine leukemia viruses. Following this finding, other similar factors restricting H.....
    Document: Clearly the cell is not a passive participant in virus replication. In addition to the cellular pathways subverted by the virus for its own use there are inhibitory factors within cells which act as intracellular defences and whose presence inhibits or 'restricts' the virus. The first one, identified in retrovirus infected cells, was Fv1 which restricts ecotropic murine leukemia viruses. Following this finding, other similar factors restricting HIV were identified. Because of their potential importance in novel antiviral approaches, they have been extensively investigated in recent years. APOBEC3 family [83] , TRIM family [77, 84] , Tetherin [85] , IRF3 [75] , SMUG1, UNG2 [86] , SAMHD1 [87] and SLX4 [79] were well known for being involved in HIV infectivity, indicating that the viral proteins can interact and modulate their activity.

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