Author: Poltronieri, Palmiro; Sun, Binlian; Mallardo, Massimo
Title: RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load Document date: 2015_10_23
ID: 259cspey_58
Snippet: As an adaptive response, viruses develop the ability to interact and deactivate these defences, a mechanism named pathogen mimicry. Among several mechanisms, there are: a) the development of proteins and molecules that act interfering with cellular processes; b) virus miRNA analogs of host miRNAs, exploiting the presence of a network of cell effectors and antiapoptotic factors; c) incorporating proteinprotein interaction domains or association mo.....
Document: As an adaptive response, viruses develop the ability to interact and deactivate these defences, a mechanism named pathogen mimicry. Among several mechanisms, there are: a) the development of proteins and molecules that act interfering with cellular processes; b) virus miRNA analogs of host miRNAs, exploiting the presence of a network of cell effectors and antiapoptotic factors; c) incorporating proteinprotein interaction domains or association modules in their genome; d) through increased mutation rates evolving the recognition domains of proteins targeted by cellular defences.
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