Author: Vergara-Alert, Júlia; Vidal, Enric; Bensaid, Albert; Segalés, Joaquim
Title: Searching for animal models and potential target species for emerging pathogens: Experience gained from Middle East respiratory syndrome (MERS) coronavirus Document date: 2017_3_3
ID: 28vx9w58_17
Snippet: New Zealand white rabbits did not exhibit clinical signs or significant gross lesions at necropsy after experimental MERS-CoV inoculation; thus, they were considered an animal model of asymptomatic infection [54] . Similar to pigs, mild to moderate rhinitis with necrosis was observed, and respiratory epithelial cells in the URT were identified as the target cells for MERS-CoV replication. Viral RNA was present in nasal swabs, and upper and lower .....
Document: New Zealand white rabbits did not exhibit clinical signs or significant gross lesions at necropsy after experimental MERS-CoV inoculation; thus, they were considered an animal model of asymptomatic infection [54] . Similar to pigs, mild to moderate rhinitis with necrosis was observed, and respiratory epithelial cells in the URT were identified as the target cells for MERS-CoV replication. Viral RNA was present in nasal swabs, and upper and lower respiratory tracts. Infectious virus was also detected in nasal swabs up to 7 days PI [54] .
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