Author: Sousa, Carole; Golebiewska, Anna; Poovathingal, Suresh K; Kaoma, Tony; Pires-Afonso, Yolanda; Martina, Silvia; Coowar, Djalil; Azuaje, Francisco; Skupin, Alexander; Balling, Rudi; Biber, Knut; Niclou, Simone P; Michelucci, Alessandro
Title: Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures Document date: 2018_9_11
ID: 0662rivp_109
Snippet: The combination of FACS and single-cell RNA-sequencing to analyse microglia in the LPS mouse model of acute inflammation reveals two distinct states of activation: a main reactive population and an intermediate activated cellular subset. These results provide insights into microglia heterogeneity and establish a resource for the identification of specific phenotypes in neurological disorders with an immunological component......
Document: The combination of FACS and single-cell RNA-sequencing to analyse microglia in the LPS mouse model of acute inflammation reveals two distinct states of activation: a main reactive population and an intermediate activated cellular subset. These results provide insights into microglia heterogeneity and establish a resource for the identification of specific phenotypes in neurological disorders with an immunological component.
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