Title: The first membrane spanning region of the lamin B receptor is sufficient for sorting to the inner nuclear membrane Document date: 1993_2_1
ID: 3qi2llmr_41
Snippet: Our data here indicate that the first transmembrane region containing the first transmembrane segment plus flanking residues on either side contribute the determinants that sort LBR to the inner nuclear membrane. Surprisingly, the nucleoplasmic domain as well as the remaining seven transmembrane regions do not appear to contain sorting determinants, at least not under the experimental conditions used here, where the sorting of exogenously introdu.....
Document: Our data here indicate that the first transmembrane region containing the first transmembrane segment plus flanking residues on either side contribute the determinants that sort LBR to the inner nuclear membrane. Surprisingly, the nucleoplasmic domain as well as the remaining seven transmembrane regions do not appear to contain sorting determinants, at least not under the experimental conditions used here, where the sorting of exogenously introduced LBR and LBR mutants is assessed in a background of endogenously expressed wild type LBR.
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