Selected article for: "RSV syncytial virus and syncytial virus"
Author: Fu, Yu; Lee, Inhan; Lee, Yong Sun; Bao, Xiaoyong
Title: Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
  • Document date: 2015_12_31
    • ID: 0b08jyjs_15
    Snippet: Probably the most convincing result is from our recent studies on a tRF-5 molecule derived from mature tRNA GluCTC (tRF5-GluCTC). Upon infection of respiratory syncytial virus (RSV), tRF5-GluCTC is induced robustly and plays a gene-silencing role on a target mRNA with a reverse complementary target sequence. In this case, the transsilencing mechanism used by this tRF was distinct from that of canonical miRNA/siRNA. Mutagenesis studies demonstrate.....
    Document: Probably the most convincing result is from our recent studies on a tRF-5 molecule derived from mature tRNA GluCTC (tRF5-GluCTC). Upon infection of respiratory syncytial virus (RSV), tRF5-GluCTC is induced robustly and plays a gene-silencing role on a target mRNA with a reverse complementary target sequence. In this case, the transsilencing mechanism used by this tRF was distinct from that of canonical miRNA/siRNA. Mutagenesis studies demonstrated that the 3ËŠ-portion of tRF5-GluCTC is critical for its gene silencing function, in contrast to miRNAs whose 5portion is the key determinant in target recognition [5] .

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