Selected article for: "rsv replication and trfs induction"
Author: Fu, Yu; Lee, Inhan; Lee, Yong Sun; Bao, Xiaoyong
Title: Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
  • Document date: 2015_12_31
    • ID: 0b08jyjs_28
    Snippet: We have demonstrated that RSV, the most common cause of bronchiolitis and pneumonia in babies, employs a novel mechanism to suppress antiviral responses via induction of some tRFs [5, 61] . We have shown that RSV infection in airway epithelial cells leads to the activation of endonuclease ANG, subsequently inducing abundant production of tRFs, most of which belong to that tRF-5 series. The cleavage sites by ANG are preferentially adjacent to the .....
    Document: We have demonstrated that RSV, the most common cause of bronchiolitis and pneumonia in babies, employs a novel mechanism to suppress antiviral responses via induction of some tRFs [5, 61] . We have shown that RSV infection in airway epithelial cells leads to the activation of endonuclease ANG, subsequently inducing abundant production of tRFs, most of which belong to that tRF-5 series. The cleavage sites by ANG are preferentially adjacent to the 5ËŠ-end of the anticodon-loop, generating tRF-5 series. These tRF-5s are localized exclusively in the cellular cytoplasm [5] . At least one of the tRFs, namely tRF5-GluCTC (tRF-5 derived from tRNA Glu ), has a trans-gene silencing function. Significantly, an antiviral target suppressed by tRF5-GluCTC downregulates RSV replication and significantly decreases the yield of infectious viral particles produced by infected cells, demonstrating a stimulatory role for tRF5-GluCTC in RSV replication [5] .

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