Author: Sztuba-Solinska, Joanna; Teramoto, Tadahisa; Rausch, Jason W.; Shapiro, Bruce A.; Padmanabhan, Radhakrishnan; Le Grice, Stuart F. J.
Title: Structural complexity of Dengue virus untranslated regions: cis-acting RNA motifs and pseudoknot interactions modulating functionality of the viral genome Document date: 2013_3_26
ID: 1pbd4maf_2
Snippet: Organization of the Dengue virus (DENV) genome represents an example of intra-genomic long distance interactions that modulate molecular processes. DENV is a mosquito-borne, single-stranded, positive (+)-sense RNA virus belonging to the Flaviviridae family, whose members are responsible for diseases of major health importance, such as yellow fever, Japanese encephalitis, tick-borne encephalitis, dengue fever and a dengue hemorrhagic fever. The DE.....
Document: Organization of the Dengue virus (DENV) genome represents an example of intra-genomic long distance interactions that modulate molecular processes. DENV is a mosquito-borne, single-stranded, positive (+)-sense RNA virus belonging to the Flaviviridae family, whose members are responsible for diseases of major health importance, such as yellow fever, Japanese encephalitis, tick-borne encephalitis, dengue fever and a dengue hemorrhagic fever. The DENV genome encodes a single-open reading frame, flanked by highly structured untranslated regions (UTRs) (5) (6) (7) . The secondary structure of DENV UTRs has attracted attention, as they have been shown to encompass motifs involved in regulation of translation, replication, transcription and viral pathogenesis (7) (8) (9) (10) .
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