Selected article for: "infection prevent and virus shedding"
Author: Fouchier, Ron A. M.
Title: Studies on Influenza Virus Transmission between Ferrets: the Public Health Risks Revisited
  • Document date: 2015_1_23
    • ID: 33f94doo_12
    Snippet: The first factor that needs to be considered is that laboratory personnel that acquired the LAI were vaccinated against the homologous A/H5N1 virus and treated with oseltamivir upon any incident with potential exposure to the virus. Although the vaccination and treatment may have been insufficient to prevent infection altogether (hence the occurrence of the LAI at a frequency of less than once every 1 million years), the virus shedding in H5vacci.....
    Document: The first factor that needs to be considered is that laboratory personnel that acquired the LAI were vaccinated against the homologous A/H5N1 virus and treated with oseltamivir upon any incident with potential exposure to the virus. Although the vaccination and treatment may have been insufficient to prevent infection altogether (hence the occurrence of the LAI at a frequency of less than once every 1 million years), the virus shedding in H5vaccinated and oseltamivir-treated individuals is likely to be reduced substantially, compared to the onward transmission in times of spread during an influenza pandemic from untreated immunologically naive individuals. If we assume a conservative 2-log reduction in virus excretion in immunized and treated individuals (20-24) compared to untreated immunologically naive individuals, the range of probability of onward transmission from a case of LAI would be reduced to Ͻ5 ϫ 10 Ϫ4 to 6 ϫ 10 Ϫ3 .

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