Selected article for: "antiviral compound and Dengue virus"
Author: Mateo, Roberto; Nagamine, Claude M.; Kirkegaard, Karla
Title: Suppression of Drug Resistance in Dengue Virus
  • Document date: 2015_12_15
    • ID: 6bx2nrui_20
    Snippet: the growth of drug-resistant viruses can be accomplished by the choice of a dominant drug target. The building blocks of the dengue virus nucleocapsid assemblage are thought to be the preassembled dimers of core protein observed in solution (24, 25) . Interestingly, the C-S34L mutation, which confers resistance to the core-targeting antiviral compound ST-148, is not located at the dimer interface (Fig. 1) , suggesting that both mutant and wild-ty.....
    Document: the growth of drug-resistant viruses can be accomplished by the choice of a dominant drug target. The building blocks of the dengue virus nucleocapsid assemblage are thought to be the preassembled dimers of core protein observed in solution (24, 25) . Interestingly, the C-S34L mutation, which confers resistance to the core-targeting antiviral compound ST-148, is not located at the dimer interface (Fig. 1) , suggesting that both mutant and wild-type proteins are capable of forming higher-order oligomers in the presence or absence of the drug (12) . Wild-type and S34L core proteins in mixed infections exhibited similar fractionation patterns, even when the patterns changed in the presence of ST-148 (Fig. 2) . Thus, it is likely that the oligomers formed in either the presence or absence of the drug contain both drug-resistant and drug-susceptible core protein.

    Search related documents:
    Co phrase search for related documents
    • absence presence and dengue virus: 1, 2, 3, 4, 5, 6, 7
    • absence presence and dimer interface: 1
    • absence presence and drug absence presence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • absence presence and drug resistant virus: 1
    • absence presence and drug target: 1, 2, 3, 4, 5
    • absence presence and high order: 1, 2
    • building block and dengue virus: 1
    • core protein and dengue virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • core protein and dominant drug target: 1
    • core protein and drug resistant virus: 1, 2, 3, 4, 5, 6
    • core protein and drug resistant virus growth: 1
    • core protein and drug target: 1, 2, 3, 4, 5, 6, 7
    • core target and dengue virus: 1, 2
    • core target and dominant drug target: 1
    • core target and drug resistant virus: 1, 2
    • core target and drug target: 1, 2, 3, 4, 5
    • core target and high order: 1
    • dengue virus and drug target: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • dengue virus and high order: 1