Selected article for: "mutant wild type and wild type"
Author: Mateo, Roberto; Nagamine, Claude M.; Kirkegaard, Karla
Title: Suppression of Drug Resistance in Dengue Virus
  • Document date: 2015_12_15
    • ID: 6bx2nrui_20
    Snippet: the growth of drug-resistant viruses can be accomplished by the choice of a dominant drug target. The building blocks of the dengue virus nucleocapsid assemblage are thought to be the preassembled dimers of core protein observed in solution (24, 25) . Interestingly, the C-S34L mutation, which confers resistance to the core-targeting antiviral compound ST-148, is not located at the dimer interface (Fig. 1) , suggesting that both mutant and wild-ty.....
    Document: the growth of drug-resistant viruses can be accomplished by the choice of a dominant drug target. The building blocks of the dengue virus nucleocapsid assemblage are thought to be the preassembled dimers of core protein observed in solution (24, 25) . Interestingly, the C-S34L mutation, which confers resistance to the core-targeting antiviral compound ST-148, is not located at the dimer interface (Fig. 1) , suggesting that both mutant and wild-type proteins are capable of forming higher-order oligomers in the presence or absence of the drug (12) . Wild-type and S34L core proteins in mixed infections exhibited similar fractionation patterns, even when the patterns changed in the presence of ST-148 (Fig. 2) . Thus, it is likely that the oligomers formed in either the presence or absence of the drug contain both drug-resistant and drug-susceptible core protein.

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