Author: Mateo, Roberto; Nagamine, Claude M.; Kirkegaard, Karla
Title: Suppression of Drug Resistance in Dengue Virus Document date: 2015_12_15
ID: 6bx2nrui_23
Snippet: It is intriguing that the two mutations conferring MK-0608 resistance identified in this work mapped to the methyltransferase domain of NS5 (Fig. 3D) . The methyltransferase and polymerase domains are known to interact functionally and structurally (16, 26) . Thus, it is possible either that the A60T and Y201H mutations exert allosteric effects on the polymerase active site or that MK-0608 inhibits methyltransferase activity directly. Whatever th.....
Document: It is intriguing that the two mutations conferring MK-0608 resistance identified in this work mapped to the methyltransferase domain of NS5 (Fig. 3D) . The methyltransferase and polymerase domains are known to interact functionally and structurally (16, 26) . Thus, it is possible either that the A60T and Y201H mutations exert allosteric effects on the polymerase active site or that MK-0608 inhibits methyltransferase activity directly. Whatever the particular step of RNA synthesis inhibited by MK-0608, it does not appear to be a dominant drug target. It is possible that other aspects of NS5 function, such as RNA binding, elongation, or translocation, will be targets (27) .
Search related documents:
Co phrase search for related documents- active site and inhibit RNA synthesis: 1
- active site and methyltransferase activity: 1, 2, 3
- active site and methyltransferase domain: 1, 2, 3, 4, 5, 6, 7, 8
- active site and polymerase active site: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37
- active site and polymerase methyltransferase: 1, 2, 3, 4
- active site and RNA binding: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57
- active site and RNA synthesis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42
- active site and work identify: 1
- allosteric effect and drug target: 1
- allosteric effect and RNA binding: 1
- dominant drug target and drug target: 1, 2
- drug target and methyltransferase activity: 1, 2
- drug target and methyltransferase domain: 1, 2
- drug target and polymerase active site: 1, 2, 3, 4
- drug target and polymerase methyltransferase: 1, 2, 3, 4, 5
- drug target and polymerase methyltransferase domain: 1
- drug target and RNA binding: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
- drug target and RNA synthesis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
- drug target and translocation elongation: 1
Co phrase search for related documents, hyperlinks ordered by date