Selected article for: "dengue virus and structural protein"
Author: Mateo, Roberto; Nagamine, Claude M.; Kirkegaard, Karla
Title: Suppression of Drug Resistance in Dengue Virus
  • Document date: 2015_12_15
    • ID: 6bx2nrui_5
    Snippet: To identify dominant drug targets in the dengue virus genome, we tested the effects of two different antiviral compounds: MK-0608, a nucleoside analog that inhibits the viral NS5 polymerase, and ST-148, a planar compound that inhibits the function of core protein, an oligomeric structural protein. Both in tissue culture and in mice, the selection of MK-0608-resistant viruses was readily observed. However, viruses resistant to ST-148 were not sele.....
    Document: To identify dominant drug targets in the dengue virus genome, we tested the effects of two different antiviral compounds: MK-0608, a nucleoside analog that inhibits the viral NS5 polymerase, and ST-148, a planar compound that inhibits the function of core protein, an oligomeric structural protein. Both in tissue culture and in mice, the selection of MK-0608-resistant viruses was readily observed. However, viruses resistant to ST-148 were not selected in tissue culture in the presence of drug-susceptible virus, and resistant viruses did not emerge during treatment of infected mice with ST-148. Thus, dengue virus core protein is a dominant drug target, and pharmaceuticals targeted against it will be less likely to be plagued by the emergence of resistant virus.

    Search related documents:
    Co phrase search for related documents
    • antiviral compound and dominant drug target: 1
    • antiviral compound and drug target: 1, 2, 3, 4, 5, 6
    • antiviral compound and infected mouse: 1
    • antiviral compound and resistant virus: 1
    • antiviral compound and resistant virus emergence: 1
    • antiviral compound and structural protein: 1, 2, 3
    • antiviral compound and tissue culture: 1
    • antiviral compound and virus genome: 1, 2, 3, 4, 5, 6, 7
    • antiviral compound and virus selection: 1
    • core protein and dengue virus core protein: 1, 2, 3
    • core protein and dominant drug target: 1
    • core protein and drug susceptible virus: 1, 2, 3, 4
    • core protein and drug target: 1, 2, 3, 4, 5, 6, 7
    • core protein and nucleoside analog: 1
    • core protein and resistant virus: 1, 2, 3, 4, 5
    • core protein and structural protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
    • core protein and tissue culture: 1, 2
    • core protein and virus core protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39
    • core protein and virus genome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10