Title: The amino-terminal domain of the lamin B receptor is a nuclear envelope targeting signal Document date: 1993_3_1
ID: 377v2ufn_34
Snippet: The findings in the present study demonstrate that the nucleoplasmic amino-terminal domain of the inner nuclear membrane LBR is transported to the nucleus after synthesis in the cytoplasm. This polypeptide is sufficient to target a type II integral membrane protein to the nuclear envelope inner membrane domain. Deletion of the amino-terminal domain from LBR weakens and perhaps abolishes the ability of the protein to reach the inner nuclear membra.....
Document: The findings in the present study demonstrate that the nucleoplasmic amino-terminal domain of the inner nuclear membrane LBR is transported to the nucleus after synthesis in the cytoplasm. This polypeptide is sufficient to target a type II integral membrane protein to the nuclear envelope inner membrane domain. Deletion of the amino-terminal domain from LBR weakens and perhaps abolishes the ability of the protein to reach the inner nuclear membrane.
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