Author: Monika Litvinukova; Carlos Talavera-Lopez; Henrike Maatz; Daniel Reichart; Catherine L. Worth; Eric L. Lindberg; Masatoshi Kanda; Krzysztof Polanski; Eirini S. Fasouli; Sara Samari; Kenny Roberts; Elizabeth Tuck; Matthias Heinig; Daniel DeLaughter; Barbara McDonough; Hiroko Wakimoto; Joshua M. Gorham; Emily Nadelmann; Krishnaa T. Mahbubani; Kourosh Saeb-Parsy; Giannino Patone; Joseph J Boyle; Hongbo Zhang; Hao Zhang; Anissa Viveiros; Gavin Oudit; Omer Bayraktar; J. G. Seidman; Christine Seidman; Michela Noseda; Norbert Hubner; Sarah A. Teichmann
Title: Cells and gene expression programs in the adult human heart Document date: 2020_4_5
ID: 1ilforzm_12
Snippet: In contrast, vCM expressed 79 genes with 3-fold higher expression than aCM ( Supplementary Table B1 ). Genes with significantly enriched expression included 7 . CC-BY-NC 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.03.024075 doi: bioRxiv preprint prototypic sarcomere protein genes MYH7 , MYL2 , and transcription f.....
Document: In contrast, vCM expressed 79 genes with 3-fold higher expression than aCM ( Supplementary Table B1 ). Genes with significantly enriched expression included 7 . CC-BY-NC 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.03.024075 doi: bioRxiv preprint prototypic sarcomere protein genes MYH7 , MYL2 , and transcription factors ( IRX3, IRX5, IRX6, MASP1, HEY2 ). vCM also had 20-fold higher expression of PRDM16 than aCM, which harbors damaging variants associated with LV non-compaction 12 Table B3 ), supporting a biological basis for this subpopulation 8 . Although cardiac functions of PRELID2 remain unknown, it is developmentally expressed during mid-gestation 15 . Using smFISH of four markers simultaneously in tissue sections, we confirmed enriched PRELID2 expression in RV ( Figure 2G ). In comparison to other subpopulations, vCM2 had highest expression of MYH6 and CDH13 , a cell surface T-cadherin receptor for the cardioprotective hormone adiponectin and low density lipoproteins, both of which are associated with multiple cardiometabolic traits 16, 17 .
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