Title: The v-sis oncoprotein loses transforming activity when targeted to the early Golgi complex Document date: 1994_12_2
ID: 2otgb2w8_3
Snippet: Since receptor autophosphorylation represents a key event in activating PDGF-mediated signaling pathways (Williams, 1989) , these intracellular forms of the receptors may be able to transmit signals that lead to autocrine transformation of cells. However, it is not clear whether the downstream effectors of PDGF-stimulated signaling are accessible from intracellular compartments. Bejcek et al. (1992) have demonstrated that internally activated rec.....
Document: Since receptor autophosphorylation represents a key event in activating PDGF-mediated signaling pathways (Williams, 1989) , these intracellular forms of the receptors may be able to transmit signals that lead to autocrine transformation of cells. However, it is not clear whether the downstream effectors of PDGF-stimulated signaling are accessible from intracellular compartments. Bejcek et al. (1992) have demonstrated that internally activated receptors may associate with PI-3 kinase in a manner similar to mature cell surface PDGF receptors, suggesting that these receptors may indeed be capable of signaling from within the cell.
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