Author: Otomaru, Hirono; Kamigaki, Taro; Tamaki, Raita; Okamoto, Michiko; Alday, Portia Parian; Tan, Alvin Gue; Manalo, Joanna Ina; Segubre-Mercado, Edelwisa; Inobaya, Marianette Tawat; Tallo, Veronica; Lupisan, Socorro; Oshitani, Hitoshi
Title: Transmission of Respiratory Syncytial Virus Among Children Under 5 Years in Households of Rural Communities, the Philippines Document date: 2019_3_11
ID: 0jfvik7w_1
Snippet: The RSV infection incidence is generally high in young infants (<6 months old) [4] , who are prone to severe diseases due to physical and immunological immaturity [5] . However, because the neutralizing antibody response is low in young infants, vaccines that mimic natural infection may be ineffective if administered to infants before they reach 4 months of age [6] . Maternal antibodies are associated with a lower risk of infection in infants whe.....
Document: The RSV infection incidence is generally high in young infants (<6 months old) [4] , who are prone to severe diseases due to physical and immunological immaturity [5] . However, because the neutralizing antibody response is low in young infants, vaccines that mimic natural infection may be ineffective if administered to infants before they reach 4 months of age [6] . Maternal antibodies are associated with a lower risk of infection in infants when antibody titers are maintained above the level considered protective during early infancy [7] [8] [9] . Therefore, an alternative vaccination strategy would be to transfer high concentrations of RSV-specific antibody via maternal vaccination, which could provide protection to infants up to 6 months of age, and to combine this approach with active vaccination in infants [10] .
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