Author: Otomaru, Hirono; Kamigaki, Taro; Tamaki, Raita; Okamoto, Michiko; Alday, Portia Parian; Tan, Alvin Gue; Manalo, Joanna Ina; Segubre-Mercado, Edelwisa; Inobaya, Marianette Tawat; Tallo, Veronica; Lupisan, Socorro; Oshitani, Hitoshi
Title: Transmission of Respiratory Syncytial Virus Among Children Under 5 Years in Households of Rural Communities, the Philippines Document date: 2019_3_11
ID: 0jfvik7w_1
Snippet: The RSV infection incidence is generally high in young infants (<6 months old) [4] , who are prone to severe diseases due to physical and immunological immaturity [5] . However, because the neutralizing antibody response is low in young infants, vaccines that mimic natural infection may be ineffective if administered to infants before they reach 4 months of age [6] . Maternal antibodies are associated with a lower risk of infection in infants whe.....
Document: The RSV infection incidence is generally high in young infants (<6 months old) [4] , who are prone to severe diseases due to physical and immunological immaturity [5] . However, because the neutralizing antibody response is low in young infants, vaccines that mimic natural infection may be ineffective if administered to infants before they reach 4 months of age [6] . Maternal antibodies are associated with a lower risk of infection in infants when antibody titers are maintained above the level considered protective during early infancy [7] [8] [9] . Therefore, an alternative vaccination strategy would be to transfer high concentrations of RSV-specific antibody via maternal vaccination, which could provide protection to infants up to 6 months of age, and to combine this approach with active vaccination in infants [10] .
Search related documents:
Co phrase search for related documents- active vaccination and low risk: 1, 2, 3
- active vaccination and maternal vaccination: 1, 2, 3
- active vaccination and natural infection: 1
- alternative vaccination strategy and antibody response: 1
- antibody response and early infancy: 1
- antibody response and high concentration: 1, 2, 3
- antibody response and infant infection: 1, 2
- antibody response and infection incidence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- antibody response and low risk: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- antibody response and maternal antibody: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- antibody response and maternal vaccination: 1, 2, 3, 4, 5, 6, 7
- antibody response and natural infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- antibody response and neutralize antibody response: 1, 2, 3, 4, 5, 6
- antibody titer and early infancy: 1
- antibody titer and high concentration: 1, 2
- antibody titer and infection incidence: 1, 2
- antibody titer and low risk: 1, 2, 3
- antibody titer and maternal antibody: 1, 2, 3, 4
- antibody titer and natural infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
Co phrase search for related documents, hyperlinks ordered by date