Author: Draz, Mohamed Shehata; Shafiee, Hadi
Title: Applications of gold nanoparticles in virus detection Document date: 2018_2_15
ID: 1xjmlwqr_66
Snippet: A AuNPs-based SERS assay for HBV DNA detection was developed following a sandwich assay format performed on a heat-responsive hybrid silicon substrate modified with AuNPs. The target HBV DNA is captured on the surface of the silicon substrate and forms a sandwich complex with specifically designed AuNPs modified with DNAindocyanine green proximally to the surface, leading to high SERS signals. This heat-responsive hybrid silicon substrate-based S.....
Document: A AuNPs-based SERS assay for HBV DNA detection was developed following a sandwich assay format performed on a heat-responsive hybrid silicon substrate modified with AuNPs. The target HBV DNA is captured on the surface of the silicon substrate and forms a sandwich complex with specifically designed AuNPs modified with DNAindocyanine green proximally to the surface, leading to high SERS signals. This heat-responsive hybrid silicon substrate-based SERS platform can detect remarkably low HBV DNA concentrations of ~0.44 fM at 25 °C and ~0.14 fM at 37 °C [17] .
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