Selected article for: "HLA class and human HLA class"
Title: Signal recognition particle-dependent membrane insertion of mouse invariant chain: a membrane-spanning protein with a cytoplasmically exposed amino terminus
  • Document date: 1986_6_1
    • ID: 4sw25blb_4
    Snippet: Invariant (li) chain (also called l-r-chain) is thought to be a type II membrane-spanning glycoprotein (13, 31) . It is found intracellularly assembled with mouse Ia and human HLA-DR (class II) histocompatibility antigens (23, 25, 27, 34, 43) . Assembly of li chain with class II antigens occurs already in the ER (27, 43) . During the intracellular transport, the oligomeric complex disassembles and only class II antigens appear on the cell surface.....
    Document: Invariant (li) chain (also called l-r-chain) is thought to be a type II membrane-spanning glycoprotein (13, 31) . It is found intracellularly assembled with mouse Ia and human HLA-DR (class II) histocompatibility antigens (23, 25, 27, 34, 43) . Assembly of li chain with class II antigens occurs already in the ER (27, 43) . During the intracellular transport, the oligomeric complex disassembles and only class II antigens appear on the cell surface, li chain seems to remain in a yet unidentified intracellular compartment (27, 43) .

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