Selected article for: "immune response and murine model"
Author: Park, Jeong-In; Song, Kyung-Hee; Jung, Seung-Youn; Ahn, Jiyeon; Hwang, Sang-Gu; Kim, Joon; Kim, Eun Ho; Song, Jie-Young
Title: Tumor-Treating Fields Induce RAW264.7 Macrophage Activation Via NK-?B/MAPK Signaling Pathways
  • Document date: 2019_8_11
    • ID: 65s65ojc_2
    Snippet: Emerging evidence has demonstrated that the tumor microenvironment may greatly contribute to the final outcome of cancer treatment modalities. Several types of cells including leukocytes, fibroblasts, and vascular endothelial cells form the tumor microenvironment, which has immune cells as its major component. 8 These immune cells interact with tumor cells to influence the initiation, proliferation, elimination, invasion, and metastasis of tumors.....
    Document: Emerging evidence has demonstrated that the tumor microenvironment may greatly contribute to the final outcome of cancer treatment modalities. Several types of cells including leukocytes, fibroblasts, and vascular endothelial cells form the tumor microenvironment, which has immune cells as its major component. 8 These immune cells interact with tumor cells to influence the initiation, proliferation, elimination, invasion, and metastasis of tumors. 9 In particular, tumor-associated macrophages are immune cells that orchestrate various factors in the tumor microenvironment through the polarization of M1 or M2 macrophages. 8, 10, 11 Tumor-associated macrophages play a crucial role in the link between inflammation and cancer to produce inflammatory cytokines, such as interleukin (IL) 1b, interferon g, IL-12, and IL-23, along with anti-inflammatory mediators (IL-4, IL-10, and IL-13). [12] [13] [14] [15] Despite increasing studies of the effect of TTFs on cancers, the influence of TTFs on immune cells has not yet been determined. Therefore, to further understand the mechanism underlying the beneficial effects of TTFs therapy and further improve this treatment modality, we investigated the influence of TTFs exposure on the function of murine macrophage RAW 264.7 cells, a frequently used in vitro model to investigate the immune response and inflammation.

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