Selected article for: "current shortage response and epidemiologic impact"
Author: Wu, Joseph T.; Peak, Corey M.; Leung, Gabriel M.; Lipsitch, Marc
Title: Fractional Dosing of Yellow Fever Vaccine to Extend Supply: A Modeling Study
  • Document date: 2016_11_10
    • ID: 02pjdufw_76
    Snippet: We searched PubMed and Google Scholar on June 10, 2016, with the terms "yellow fever" and "vaccine" or "dose sparing". We did not find any reports of randomized trials of yellow fever (YF) vaccine efficacy, at full or lower doses. Three relatively recent studies suggest similar immunological responses at five-fold, or more, fractionation as compared to the current dose antigen levels. 8, 9, 27 While several recent perspective articles propose the.....
    Document: We searched PubMed and Google Scholar on June 10, 2016, with the terms "yellow fever" and "vaccine" or "dose sparing". We did not find any reports of randomized trials of yellow fever (YF) vaccine efficacy, at full or lower doses. Three relatively recent studies suggest similar immunological responses at five-fold, or more, fractionation as compared to the current dose antigen levels. 8, 9, 27 While several recent perspective articles propose the dose-sparing strategy in response to the current shortage, 2-4 to our knowledge this is the first study to test the robustness of this strategy (in terms of its epidemiologic impact) against the uncertainties surrounding fractional-dose YF vaccine efficacy and mode of action (e.g. "all-or-nothing" and "leaky").

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