Selected article for: "dose fractionation and fractional dose vaccine"
Author: Wu, Joseph T.; Peak, Corey M.; Leung, Gabriel M.; Lipsitch, Marc
Title: Fractional Dosing of Yellow Fever Vaccine to Extend Supply: A Modeling Study
  • Document date: 2016_11_10
    • ID: 02pjdufw_76
    Snippet: We searched PubMed and Google Scholar on June 10, 2016, with the terms "yellow fever" and "vaccine" or "dose sparing". We did not find any reports of randomized trials of yellow fever (YF) vaccine efficacy, at full or lower doses. Three relatively recent studies suggest similar immunological responses at five-fold, or more, fractionation as compared to the current dose antigen levels. 8, 9, 27 While several recent perspective articles propose the.....
    Document: We searched PubMed and Google Scholar on June 10, 2016, with the terms "yellow fever" and "vaccine" or "dose sparing". We did not find any reports of randomized trials of yellow fever (YF) vaccine efficacy, at full or lower doses. Three relatively recent studies suggest similar immunological responses at five-fold, or more, fractionation as compared to the current dose antigen levels. 8, 9, 27 While several recent perspective articles propose the dose-sparing strategy in response to the current shortage, 2-4 to our knowledge this is the first study to test the robustness of this strategy (in terms of its epidemiologic impact) against the uncertainties surrounding fractional-dose YF vaccine efficacy and mode of action (e.g. "all-or-nothing" and "leaky").

    Search related documents:
    Co phrase search for related documents
    • current shortage and epidemiologic impact: 1
    • current shortage and fractional dose: 1
    • current shortage and fractional dose mode YF vaccine efficacy: 1
    • current shortage and immunological response: 1
    • current shortage and mode YF vaccine efficacy: 1
    • current shortage response and epidemiologic impact: 1
    • current shortage response and fractional dose: 1
    • current shortage response and fractional dose mode YF vaccine efficacy: 1
    • current shortage response and mode YF vaccine efficacy: 1
    • epidemiologic impact and fractional dose: 1, 2
    • epidemiologic impact and fractional dose mode YF vaccine efficacy: 1
    • epidemiologic impact and low dose: 1
    • epidemiologic impact and mode YF vaccine efficacy: 1
    • epidemiologic impact and randomized trial: 1
    • fractional dose and low dose: 1, 2, 3
    • fractional dose and mode YF vaccine efficacy: 1
    • fractional dose and randomized trial: 1, 2
    • fractional dose mode YF vaccine efficacy and mode YF vaccine efficacy: 1
    • Google Scholar PubMed search and low dose: 1, 2, 3