Author: Won, Hokeun; Lee, Dong-Uk; Jang, Guehwan; Noh, Yun-Hee; Lee, Seung-Chul; Choi, Hwan-Won; Yoon, In-Joong; Yoo, Han Sang; Lee, Changhee
Title: Generation and protective efficacy of a cold-adapted attenuated genotype 2b porcine epidemic diarrhea virus Document date: 2019_7_9
ID: 2hxlx1j2_42
Snippet: Ten piglets per litter were allocated to each sow and were nursed by their dam. At day 4 post-farrowing, all neonates in groups 1 and 2 were orally exposed to the virulent Aram-P5 virus. In contrast, nursing piglets in group 3 were mock-inoculated with MEM. Clinical signs were recorded daily, and fecal swabs were collected before and after the challenge for the duration of the study. During the pre-challenge period, all piglets were healthy and h.....
Document: Ten piglets per litter were allocated to each sow and were nursed by their dam. At day 4 post-farrowing, all neonates in groups 1 and 2 were orally exposed to the virulent Aram-P5 virus. In contrast, nursing piglets in group 3 were mock-inoculated with MEM. Clinical signs were recorded daily, and fecal swabs were collected before and after the challenge for the duration of the study. During the pre-challenge period, all piglets were healthy and had no clinical symptoms showing normal fecal consistency without PEDV shedding. Following the challenge, PEDV-exposed piglets from unvaccinated sows (group 2) developed clinical symptoms, including anorexia and diarrhea by 1 DPC (mean CSS of > 2.4) and suffered from severe watery diarrhea with vomiting thereafter (Fig. 8A) challenge period. These results demonstrated that litters from vaccinated sows significantly mitigated diarrhea after the challenge compared to those from unvaccinated sows.
Search related documents:
Co phrase search for related documents- challenge period and vaccinated sow: 1
- clinical sign and diarrhea anorexia: 1, 2, 3, 4
- clinical sign and diarrhea anorexia include: 1
Co phrase search for related documents, hyperlinks ordered by date