Selected article for: "lung function and subepithelial basement"
Author: Hur, Gyu Young; Broide, David H.
Title: Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma
  • Document date: 2019_6_4
    • ID: 6j3k3viu_1
    Snippet: Asthma is a common disorder of the airways characterized by airway inflammation and in a subset of asthmatics by decline in lung function and airway remodeling. The estimated prevalence of asthma in the United States is approximately 8.6% for adults and 8.3% for children in 2016. 1 In Korea, the prevalence of asthma is estimated as 3.1% of adults in 2017, 2 and 5.3%-9.1% of children (age 6-15 years) in 2010. A subset of asthmatics develops declin.....
    Document: Asthma is a common disorder of the airways characterized by airway inflammation and in a subset of asthmatics by decline in lung function and airway remodeling. The estimated prevalence of asthma in the United States is approximately 8.6% for adults and 8.3% for children in 2016. 1 In Korea, the prevalence of asthma is estimated as 3.1% of adults in 2017, 2 and 5.3%-9.1% of children (age 6-15 years) in 2010. A subset of asthmatics develops decline in lung function and airway remodeling which this review focuses on. Airway remodeling is characterized by structural changes including airway smooth muscle hypertrophy/ hyperplasia, subepithelial fibrosis due to thickening of the reticular basement membrane, mucus metaplasia of the epithelium, and angiogenesis. 3 Epidemiologic studies suggest that both genetic and environmental factors may contribute to decline in lung function and airway remodeling in a subset of asthmatics.

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