Selected article for: "asthma lung function decline and lung function"
Author: Hur, Gyu Young; Broide, David H.
Title: Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma
  • Document date: 2019_6_4
    • ID: 6j3k3viu_37
    Snippet: ARG converts L-arginine into L-ornithine and urea, and may thus be involved in the pathogenesis of asthma through dysregulation of L-arginine metabolism and modulation of nitric oxide homeostasis. 55 ARG has 2 isoenzymes, ARG1 and ARG2, and SNPs in these genes have been studied in relation to asthma, but not in relation to decline in lung function or airway remodeling. The ARG2 SNPs rs17249437 and rs3742879 were significantly associated with decr.....
    Document: ARG converts L-arginine into L-ornithine and urea, and may thus be involved in the pathogenesis of asthma through dysregulation of L-arginine metabolism and modulation of nitric oxide homeostasis. 55 ARG has 2 isoenzymes, ARG1 and ARG2, and SNPs in these genes have been studied in relation to asthma, but not in relation to decline in lung function or airway remodeling. The ARG2 SNPs rs17249437 and rs3742879 were significantly associated with decreased FEV1% in an asthmatic family study (P = 0.020 and P = 0.013). 55 However, none of the investigated SNPs in ARG1 and ARG2 showed a significant association with FEV1 decline in longitudinal observation for 10.3 years. There have been no reports of ARG1 or ARG2 genetic polymorphisms and airway remodeling in asthma.

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