Author: William Binning; Aja E. Hogan-Cann; Diana Yae Sakae; Matthew Maksoud; Valeriy Ostapchenko; Mohammed Al-Onaizi; Sara Matovic; Wei-Yang Lu; Marco A. M. Prado; Wataru Inoue; Vania F. Prado
Title: Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice Document date: 2020_1_28
ID: ely200x3_103
Snippet: Using the Cre-lox system to drive specific and inducible expression of hM3Dq in microglia, we dissected the action of muscarinic M3 receptor (the hM3Dq progenitor) signaling in these cells in vivo, with implications for other GPCRs that are also Gq-associated. Our results demonstrate that acute activation of microglial hM3Dq-signaling enhances the production of pro-inflammatory cytokines in the brain. In contrast, chronic activation of this pathw.....
Document: Using the Cre-lox system to drive specific and inducible expression of hM3Dq in microglia, we dissected the action of muscarinic M3 receptor (the hM3Dq progenitor) signaling in these cells in vivo, with implications for other GPCRs that are also Gq-associated. Our results demonstrate that acute activation of microglial hM3Dq-signaling enhances the production of pro-inflammatory cytokines in the brain. In contrast, chronic activation of this pathway attenuates LPS-mediated cytokine expression and sickness behavior.
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