Author: Sztuba-Solinska, Joanna; Teramoto, Tadahisa; Rausch, Jason W.; Shapiro, Bruce A.; Padmanabhan, Radhakrishnan; Le Grice, Stuart F. J.
Title: Structural complexity of Dengue virus untranslated regions: cis-acting RNA motifs and pseudoknot interactions modulating functionality of the viral genome Document date: 2013_3_26
ID: 1pbd4maf_51
Snippet: Considering that DENV RNA must assume alternative conformations (39) to fulfill a continuous need to function as mRNA, the replication template, as well as the viral genome, we must bear in mind that the structure reported here may be only partially representative of the in vivo viral RNA population. Further studies will address folding of DENV RNA at different stage of viral life cycle to understand the mechanisms that modulate multifunctionalit.....
Document: Considering that DENV RNA must assume alternative conformations (39) to fulfill a continuous need to function as mRNA, the replication template, as well as the viral genome, we must bear in mind that the structure reported here may be only partially representative of the in vivo viral RNA population. Further studies will address folding of DENV RNA at different stage of viral life cycle to understand the mechanisms that modulate multifunctionality of viral RNA and, as a result, promote rational design of live attenuated vaccines and/or antiviral therapeutics.
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