Title: The v-sis oncoprotein loses transforming activity when targeted to the early Golgi complex Document date: 1994_12_2
ID: 2otgb2w8_1
Snippet: T RANSFORMATION and tumorigenesis are frequently associated with the abnormal expression of growth factors and their receptors. Many oncogenes have been shown to be homologues of normal cellular proteins, as in the case of the retroviral oncogene v-sis , which is homologous with the B chain of plateletderived growth factor (PDGF) (Doolittle et al., 1983; Waterfield et al., 1983) . Expression of the v-sis protein activates cellular PDGF receptors,.....
Document: T RANSFORMATION and tumorigenesis are frequently associated with the abnormal expression of growth factors and their receptors. Many oncogenes have been shown to be homologues of normal cellular proteins, as in the case of the retroviral oncogene v-sis , which is homologous with the B chain of plateletderived growth factor (PDGF) (Doolittle et al., 1983; Waterfield et al., 1983) . Expression of the v-sis protein activates cellular PDGF receptors, resulting in the stimulation of signal transduction pathways that ultimately leads to cellular transformation.
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