Title: The v-sis oncoprotein loses transforming activity when targeted to the early Golgi complex Document date: 1994_12_2
ID: 2otgb2w8_61
Snippet: It has also been demonstrated that suramin treatment of v-sis-transformed cells reverts the transformed phenotype (Fleming et al., 1989) , and that suramin decreases phosphorylation levels of cell-surface PDGF receptors with little effect on intracellular receptor phosphorylation. These experiments suggest that v-sis protein can interact with intracellular forms of the PDGF receptors in cells and stimulate autophosphorylation activity of these im.....
Document: It has also been demonstrated that suramin treatment of v-sis-transformed cells reverts the transformed phenotype (Fleming et al., 1989) , and that suramin decreases phosphorylation levels of cell-surface PDGF receptors with little effect on intracellular receptor phosphorylation. These experiments suggest that v-sis protein can interact with intracellular forms of the PDGF receptors in cells and stimulate autophosphorylation activity of these immature receptors, but that activated receptors must reach a suramin-sensitive, cell surface location in order to trigger the signal transduction cascade that leads to transformation.
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