Author: Sun, Shihui; Jiang, Yuting; Wang, Renxi; Liu, Chenfeng; Liu, Xiaoling; Song, Nianping; Guo, Yan; Guo, Renfeng; Du, Lanying; Jiang, Shibo; Li, Yan; Qiu, Zewu; Zhao, Guangyu; Zhou, Yusen
Title: Treatment of Paraquat-Induced Lung Injury With an Anti-C5a Antibody: Potential Clinical Application* Document date: 2018_4_13
ID: 6ztwho9k_24
Snippet: To determine the effect of anti-C5a treatment on the local and systemic inflammatory responses initiated by paraquat, we measured inflammatory cytokines and chemokines in serum samples. Paraquat administration led to a significant increase in the serum concentration of all cytokines/chemokines tested. However, IFX-1 led to a significant reduction in serum IL-1β, IL-6, TNF-α, and MCP-1 (Fig. 2) . IFX-1 also caused a significant reduction in plas.....
Document: To determine the effect of anti-C5a treatment on the local and systemic inflammatory responses initiated by paraquat, we measured inflammatory cytokines and chemokines in serum samples. Paraquat administration led to a significant increase in the serum concentration of all cytokines/chemokines tested. However, IFX-1 led to a significant reduction in serum IL-1β, IL-6, TNF-α, and MCP-1 (Fig. 2) . IFX-1 also caused a significant reduction in plasma concentrations of C5a (p < 0.001), but not C3a or C5b-9 (Supplemental Fig. 5A , Supplemental Digital Content 7, http://links.lww.com/CCM/D165; legend, Supplemental Digital Content 1, http://links.lww.com/CCM/ D159). These data suggest that IFX-1 is highly specific for C5a.
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