Selected article for: "inflammatory damage and lung inflammatory damage"
Author: Sun, Shihui; Jiang, Yuting; Wang, Renxi; Liu, Chenfeng; Liu, Xiaoling; Song, Nianping; Guo, Yan; Guo, Renfeng; Du, Lanying; Jiang, Shibo; Li, Yan; Qiu, Zewu; Zhao, Guangyu; Zhou, Yusen
Title: Treatment of Paraquat-Induced Lung Injury With an Anti-C5a Antibody: Potential Clinical Application*
  • Document date: 2018_4_13
    • ID: 6ztwho9k_34
    Snippet: Plasma obtained from paraquat patients activated blood granulocytes; this was completely abolished by IFX-1. In addition, targeting C5a with IFX-1 led to a marked weakening of the inflammatory responses and alleviated tissue damage, especially in the lung, kidney, and spleen. We also detected the complement activation in patients with ALI suffering from other chemical poisoning, including pesticides and herbicides (data not shown), the results sh.....
    Document: Plasma obtained from paraquat patients activated blood granulocytes; this was completely abolished by IFX-1. In addition, targeting C5a with IFX-1 led to a marked weakening of the inflammatory responses and alleviated tissue damage, especially in the lung, kidney, and spleen. We also detected the complement activation in patients with ALI suffering from other chemical poisoning, including pesticides and herbicides (data not shown), the results showed that C5a was elevated significantly, indicating the possible role of C5a in lung injury induced by these types of chemical poisonings. These results suggest that blocking complement activation is an effective therapeutic approach to the treatment of ALI induced by toxic agents such as paraquat.

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