Selected article for: "chemical poisoning and lung injury"
Author: Sun, Shihui; Jiang, Yuting; Wang, Renxi; Liu, Chenfeng; Liu, Xiaoling; Song, Nianping; Guo, Yan; Guo, Renfeng; Du, Lanying; Jiang, Shibo; Li, Yan; Qiu, Zewu; Zhao, Guangyu; Zhou, Yusen
Title: Treatment of Paraquat-Induced Lung Injury With an Anti-C5a Antibody: Potential Clinical Application*
  • Document date: 2018_4_13
    • ID: 6ztwho9k_6
    Snippet: Chemical poisoning is a major cause of morbidity and mortality worldwide. More than 2 million cases of chemical poisoning including paraquat are reported annually in China, resulting in over 150,000 deaths (18) (19) (20) (21) . Death in paraquat poisoning is either due to significant ALI or multiple organ failure (22) . Oxygen-free radicals was reported to play a role in lung injury caused by paraquat poisoning (23) . Interaction of C5a with C5aR.....
    Document: Chemical poisoning is a major cause of morbidity and mortality worldwide. More than 2 million cases of chemical poisoning including paraquat are reported annually in China, resulting in over 150,000 deaths (18) (19) (20) (21) . Death in paraquat poisoning is either due to significant ALI or multiple organ failure (22) . Oxygen-free radicals was reported to play a role in lung injury caused by paraquat poisoning (23) . Interaction of C5a with C5aR could activate neutrophils and monocytes to generate oxidative burst with release of reactive oxygen species (ROS) (24, 25) , whereas interception of C5a-C5aR signaling significantly inhibited oxidative burst in neutrophils induced with Escherichia coli. and in whole blood induced with Neisseria meningitides (26, 27) . Therefore, it is possible that blockade of C5a could effectively alleviate ALI induced by paraquat poisoning through the reduction of ROS release.

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