Selected article for: "immune response and viral infection"
Author: Wang, Ziqiang; Zhao, Yiwan; Zhang, Yaou
Title: Viral lncRNA: A regulatory molecule for controlling virus life cycle
  • Document date: 2017_3_23
    • ID: 213ddk0s_26
    Snippet: In this review, we have thoroughly described the biological roles of lncRNAs in enhancing viral gene expression, promoting viral replication and genome packaging, boosting virion release, maintaining viral latency, assisting viral transformation, and antagonizing the host antiviral innate immune response. More importantly, in view of their regulatory roles, lncRNAs have been regarded as targets to block the facilitation of viral infection. Since .....
    Document: In this review, we have thoroughly described the biological roles of lncRNAs in enhancing viral gene expression, promoting viral replication and genome packaging, boosting virion release, maintaining viral latency, assisting viral transformation, and antagonizing the host antiviral innate immune response. More importantly, in view of their regulatory roles, lncRNAs have been regarded as targets to block the facilitation of viral infection. Since the viral life cycle and the mechanism of the host antiviral response are clearer, targeting lncRNAs for prophylactic or therapeutic ends is an attractive alternative. With further advances in our understanding of the molecular details that govern the viral life cycle and immune response, this review hopefully revealed information that will help expand viral intervention strategies.

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