Virus- and Interferon Alpha-Induced Transcriptomes of Cells from the Microbat Myotis daubentonii

Hölzer, Martin; Schoen, Andreas; Wulle, Julia; Müller, Marcel A.; Drosten, Christian; Marz, Manja; Weber, Friedemann

Thus, previous studies on virus-induced or IFN-stimulated transcriptional profiles of cells overwhelmingly focused on megabats (family Pteropodidae) of the suborder Yinpterochiroptera. This suborder contains 7 bat families, whereas the Yangochiroptera, having separated around 60 million years ago, contain 14 families (Teeling et al., 2018) . Yangochiroptera species host SARS-like coronaviruses (Drexler et al., 2011) , rhabdoviruses and flaviviruses (Calisher et al., 2006) , paramyxoviruses (Drexler et al., 2012) , and bunyaviruses such as Crimean-Congo hemorrhagic fever-like virus (Muller et al., 2016) , Hantavirus (Weiss et al., 2012) , or Rift Valley fever virus (Calisher et al., 2006; Oelofsen and Van der Ryst, 1999) . Nonetheless, for Yangochiroptera microbats there are (1) no studies on the transcriptomal cell responses to an IFN-inducing virus and (2) only one study on the IFN-stimulated gene expression profile (Shaw et al., 2017) , which, however, focused on conserved ISGs. Moreover, to our knowledge a side-by-side, global comparison of early and late transcriptomes of cells in response to either virus or IFN is not available for any organism.