Selected article for: "gene expression and viral gene expression"
Author: Wang, Ziqiang; Zhao, Yiwan; Zhang, Yaou
Title: Viral lncRNA: A regulatory molecule for controlling virus life cycle
  • Document date: 2017_3_23
    • ID: 213ddk0s_5
    Snippet: Once a virus reaches the appropriate cell compartment, the viral genome must direct the expression of "early" proteins, which will enable genome replication, and "late" proteins, which are used to package the viral genome and assemble the capsid. In cells infected with the dengue or kunjin viruses, subgenomic flavivirus RNA (sfRNA), which is a lncRNA that is incompletely degraded from the viral genomic RNA presumably by the cellular 5' -3 0 exori.....
    Document: Once a virus reaches the appropriate cell compartment, the viral genome must direct the expression of "early" proteins, which will enable genome replication, and "late" proteins, which are used to package the viral genome and assemble the capsid. In cells infected with the dengue or kunjin viruses, subgenomic flavivirus RNA (sfRNA), which is a lncRNA that is incompletely degraded from the viral genomic RNA presumably by the cellular 5' -3 0 exoribonuclease XRN1, inhibits XRN1 activity and alters host mRNA stability. This effect may assist the stabilization of viral transcripts and disrupt the regulation of host cell gene expression [6] .

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