Author: Welch, Matthew D.
Title: Why should cell biologists study microbial pathogens? Document date: 2015_12_1
ID: 04xyhhmf_24
Snippet: Beyond autophagy, the study of pathogens has revealed previously unappreciated pathways for regulating programmed cell death that are integral to innate immunity and inflammation. One such pathway was discovered by studying cell death induced by S. Typhimurium. It was noted that S. Typhimurium infection induced cell death in macrophages that was dependent on caspase-1 (Hersh et al., 1999) . Moreover, the characteristics of death were distinct fro.....
Document: Beyond autophagy, the study of pathogens has revealed previously unappreciated pathways for regulating programmed cell death that are integral to innate immunity and inflammation. One such pathway was discovered by studying cell death induced by S. Typhimurium. It was noted that S. Typhimurium infection induced cell death in macrophages that was dependent on caspase-1 (Hersh et al., 1999) . Moreover, the characteristics of death were distinct from apoptosis in key respects, including diffuse rather than com-
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