Author: George, Melissa R
Title: Hemophagocytic lymphohistiocytosis: review of etiologies and management Document date: 2014_6_12
ID: 3frxd1c1_43
Snippet: Hemophagocytic lymphohistiocytosis protocols include systemic treatment with dexamethasone, which can cross the blood-brain barrier. For patients with persistent cerebrospinal fluid abnormalities, intrathecal therapy such as methotrexate is recommended, despite the fact that a study of 35 patients demonstrated that the probability of achieving normalization of CNS symptoms is roughly equal with or without intrathecal therapy. 260 Given the devast.....
Document: Hemophagocytic lymphohistiocytosis protocols include systemic treatment with dexamethasone, which can cross the blood-brain barrier. For patients with persistent cerebrospinal fluid abnormalities, intrathecal therapy such as methotrexate is recommended, despite the fact that a study of 35 patients demonstrated that the probability of achieving normalization of CNS symptoms is roughly equal with or without intrathecal therapy. 260 Given the devastating cognitive, neurological, and developmental defects that can result from HLH, many would argue that the benefits of intrathecal therapies justify potential risk.
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