Author: Baum, Alina; García-Sastre, Adolfo
Title: Induction of type I interferon by RNA viruses: cellular receptors and their substrates Document date: 2009_11_1
ID: 4c1nuv2p_25
Snippet: Identification of MDA5 specific substrates and its mode of RNA recognition have proven very challenging and its specificity for long dsRNA is not understood. Currently, it appears that while RIG-I can recognize a wide size range of dsRNA molecules, MDA5 is not able to be activated by RNA shorter than approximately 2 kb (Kato et al. 2008) . The distinction by RIG-I and MDA5 of such large RNA molecules is difficult to explain since the proteins are.....
Document: Identification of MDA5 specific substrates and its mode of RNA recognition have proven very challenging and its specificity for long dsRNA is not understood. Currently, it appears that while RIG-I can recognize a wide size range of dsRNA molecules, MDA5 is not able to be activated by RNA shorter than approximately 2 kb (Kato et al. 2008) . The distinction by RIG-I and MDA5 of such large RNA molecules is difficult to explain since the proteins are likely to interact with only a few dozen bases at a time. It is possible that time spent in translocation mode and the concurrent ATP hydrolysis could be critical for MDA5 specific signaling.
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