Author: Darwish, Ilyse; Miller, Chris; Kain, Kevin C.; Liles, W. Conrad
Title: Inhaled Nitric Oxide Therapy Fails to Improve Outcome in Experimental Severe Influenza Document date: 2012_1_13
ID: 1rktb6yq_15
Snippet: A high dose of NO at 160 ppm was administered intermittently, not to target the airway vessels specifically, but rather to induce an antimicrobial effect while avoiding the harmful effects of high dose continuous iNO delivery. iNO administered to influenza infected mice in this manner, either prophylactically or therapeutically, failed to improve survival of infected mice, change the course of weight loss, or decrease the lung viral load, compare.....
Document: A high dose of NO at 160 ppm was administered intermittently, not to target the airway vessels specifically, but rather to induce an antimicrobial effect while avoiding the harmful effects of high dose continuous iNO delivery. iNO administered to influenza infected mice in this manner, either prophylactically or therapeutically, failed to improve survival of infected mice, change the course of weight loss, or decrease the lung viral load, compared to control mice receiving compressed air. Therefore, although administration of high dose intermittent iNO may have reduced the harmful side-effects of NO, antimicrobial activity was not observed in vivo.
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