Author: Gershoni, Jonathan M.
Title: B-cell restriction – an alternative piece to the puzzle Document date: 2019_4_23
ID: 5ibowkyq_18
Snippet: Assuming that one has mapped the preferred neutralizing surfaces of a given virus, it might be possible to accentuate these targets by occluding and shielding otherwise distracting surfaces. Strategically placing glyco-moieties to shield surfaces of the spike protein has been proposed so to leave only the neutralizing surfaces exposed and subject to B-cell scrutiny. 44, 45 In essence, the use of trimeric spike proteins, as in the case of SOSIP tr.....
Document: Assuming that one has mapped the preferred neutralizing surfaces of a given virus, it might be possible to accentuate these targets by occluding and shielding otherwise distracting surfaces. Strategically placing glyco-moieties to shield surfaces of the spike protein has been proposed so to leave only the neutralizing surfaces exposed and subject to B-cell scrutiny. 44, 45 In essence, the use of trimeric spike proteins, as in the case of SOSIP trimers for HIV-1, ensures that the inner surfaces of gp120 "chaff decoys" are avoided. [46] [47] [48]
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