Author: Banu, Nasirah; Chia, Adeline; Ho, Zi Zong; Garcia, Alfonso Tan; Paravasivam, Komathi; Grotenbreg, Gijsbert M.; Bertoletti, Antonio; Gehring, Adam J.
Title: Building and Optimizing a Virus-specific T Cell Receptor Library for Targeted Immunotherapy in Viral Infections Document date: 2014_2_25
ID: 44w6omdp_21
Snippet: The functional impact of optimal TCR orientation was observed in the ability of redirected cells to produce antiviral cytokines in response to their cognate epitopes. The optimal orientation of the TCR cassette not only increased the frequency of cells capable of producing IFN-c but it also increased the multi-functionality of the total T cell population; increasing the frequency of both IL-2 and TNF-a producing T cells......
Document: The functional impact of optimal TCR orientation was observed in the ability of redirected cells to produce antiviral cytokines in response to their cognate epitopes. The optimal orientation of the TCR cassette not only increased the frequency of cells capable of producing IFN-c but it also increased the multi-functionality of the total T cell population; increasing the frequency of both IL-2 and TNF-a producing T cells.
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