Selected article for: "host protein and mouse human"
Author: Jaïs, Philippe H; Decroly, Etienne; Jacquet, Eric; Le Boulch, Marine; Jaïs, Aurélien; Jean-Jean, Olivier; Eaton, Heather; Ponien, Prishila; Verdier, Fréderique; Canard, Bruno; Goncalves, Sergio; Chiron, Stéphane; Le Gall, Maude; Mayeux, Patrick; Shmulevitz, Maya
Title: C3P3-G1: first generation of a eukaryotic artificial cytoplasmic expression system
  • Document date: 2019_3_18
    • ID: 6nq7y1qe_75
    Snippet: To better investigate the performance of the C3P3-G1 system in CHO-K1 cells, which is the predominant mammalian host for therapeutic protein production, the titers of three secreted proteins, human erythropoietin (hEPO), human granulocyte-colony-stimulating factor (hG-CSF), and mouse alpha-fetoprotein (mAFP) were monitored by ELISA. Compared to the standard CMV-promoter-based nuclear expression plasmid, C3P3-G1 produced at peak 1.9to 3.1-fold hig.....
    Document: To better investigate the performance of the C3P3-G1 system in CHO-K1 cells, which is the predominant mammalian host for therapeutic protein production, the titers of three secreted proteins, human erythropoietin (hEPO), human granulocyte-colony-stimulating factor (hG-CSF), and mouse alpha-fetoprotein (mAFP) were monitored by ELISA. Compared to the standard CMV-promoter-based nuclear expression plasmid, C3P3-G1 produced at peak 1.9to 3.1-fold higher titers of proteins ( Figure 11A-C) .

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