Author: Park, Jeong-In; Song, Kyung-Hee; Jung, Seung-Youn; Ahn, Jiyeon; Hwang, Sang-Gu; Kim, Joon; Kim, Eun Ho; Song, Jie-Young
Title: Tumor-Treating Fields Induce RAW264.7 Macrophage Activation Via NK-?B/MAPK Signaling Pathways Document date: 2019_8_11
ID: 65s65ojc_33
Snippet: Some of these key cytokines that play critical roles in immune and inflammatory processes include TNF-a, which is also produced by T-lymphocytes and natural killer cells, and IL-1b, which facilitates the release of activated macrophages. 35, 36 In the present study, TTFs markedly treated RAW 264.7 cells to release TNF-a and IL-1b, indicating that TTFs-stimulated macrophages contribute to provoking an inflammatory response. The levels of TNF-a, IL.....
Document: Some of these key cytokines that play critical roles in immune and inflammatory processes include TNF-a, which is also produced by T-lymphocytes and natural killer cells, and IL-1b, which facilitates the release of activated macrophages. 35, 36 In the present study, TTFs markedly treated RAW 264.7 cells to release TNF-a and IL-1b, indicating that TTFs-stimulated macrophages contribute to provoking an inflammatory response. The levels of TNF-a, IL-1b, and IL-6 were markedly higher in TTFs-treated RAW 264.7 cells cocultured with 4T1 murine mammary carcinoma cells than in 4T1 or RAW 264.7 cells with or without TTFs. Moreover, the viability of 4T1 cells treated with the CM of TTFs-stimulated RAW 264.7 cells decreased, indicating that macrophage activation by TTFs effectively killed the tumor cells.
Search related documents:
Co phrase search for related documents- critical role and inflammatory response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55
- critical role and key cytokine: 1, 2
- critical role and macrophage activation: 1, 2, 3, 4, 5, 6, 7
- critical role and natural killer: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- critical role and natural killer cell: 1, 2
- critical role and present study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52
- critical role and TNF level: 1
- critical role and TNF release: 1
- critical role and tumor cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- critical role play and inflammatory response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- critical role play and key cytokine: 1
- critical role play and macrophage activation: 1, 2
- critical role play and natural killer: 1, 2, 3, 4, 5, 6, 7
- critical role play and natural killer cell: 1
- critical role play and present study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- critical role play and tumor cell: 1, 2, 3, 4, 5, 6
- inflammatory immune process and macrophage activation: 1
Co phrase search for related documents, hyperlinks ordered by date