Selected article for: "cell surface and virus bind"
Author: Abdul-Rasool, Sahar; Fielding, Burtram C
Title: Understanding Human Coronavirus HCoV-NL63
  • Document date: 2010_5_25
    • ID: 3ahp9tli_18
    Snippet: It is well documented that SARS-CoV and HCoV-NL63 use the same receptor, angiotensin converting enzyme (ACE)-2, for entry into the host cell [41, 42] . However, the consequences following the entry are very different; SARS-CoV causes severe respiratory distress, while HCoV-NL63 might lead to a mild respiratory infection. This was attributed to the ability of each virus receptor-binding protein, spike or S protein, to bind to ACE-2 on the cell sur.....
    Document: It is well documented that SARS-CoV and HCoV-NL63 use the same receptor, angiotensin converting enzyme (ACE)-2, for entry into the host cell [41, 42] . However, the consequences following the entry are very different; SARS-CoV causes severe respiratory distress, while HCoV-NL63 might lead to a mild respiratory infection. This was attributed to the ability of each virus receptor-binding protein, spike or S protein, to bind to ACE-2 on the cell surface. It was found that the HCoV-NL63 S protein has a weaker interaction with ACE-2 than the SARS-CoV S protein. This lower-affinity interaction with ACE-2 might partly explain the different pathological consequences of infection by SARS-CoV and HCoV-NL63 [43] .

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