Selected article for: "dna vaccine and vaccine dna"
Author: Janice Oh, Hsueh-Ling; Ken-En Gan, Samuel; Bertoletti, Antonio; Tan, Yee-Joo
Title: Understanding the T cell immune response in SARS coronavirus infection
  • Document date: 2012_9_5
    • ID: 5uoepd0r_6
    Snippet: Other T cell epitopes identified include S787-795, S1042-1050 (found in the S2 domain) and S411-420 (P15) (found in the S1 domain) . 22, 23 These epitopes were found to be immunogenic and able to induce strong IFNc production from PBMCs of recovered SARS patients. At the same time, HLA-A*02:01 transgenic mice immunized with DNA vaccines encoding the S protein were able to induce significant peptide-specific response. 24 In this study, the HLA-A*0.....
    Document: Other T cell epitopes identified include S787-795, S1042-1050 (found in the S2 domain) and S411-420 (P15) (found in the S1 domain) . 22, 23 These epitopes were found to be immunogenic and able to induce strong IFNc production from PBMCs of recovered SARS patients. At the same time, HLA-A*02:01 transgenic mice immunized with DNA vaccines encoding the S protein were able to induce significant peptide-specific response. 24 In this study, the HLA-A*02:01 restricted epitope S958-966 (also known as Sp8), first identified based on HLA-A*02:01 binding peptide and proteosomal cleavage prediction systems, was found capable of inducing specific CTLs in the PBMCs of healthy individuals as well as in transgenic mice immunized with S DNA vaccine. 24 This suggests that there may already be SARS-CoV-specific CTL precursor cells within the T-cell repertoire of healthy individuals.

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