Author: Glantz-Gashai, Yitav; Meirson, Tomer; Reuveni, Eli; Samson, Abraham O
Title: Virtual screening for potential inhibitors of Mcl-1 conformations sampled by normal modes, molecular dynamics, and nuclear magnetic resonance Document date: 2017_6_19
ID: 47srfqzl_42
Snippet: As such, nilotinib is a promising candidate for Mcl-1-targeted cancer therapies. Cabergoline is an ergot derivative and a potent D2 dopamine receptor agonist used in the treatment of prolactinomas and uterine fibroids. 43 Cabergoline contains a tricyclic ring that is structurally related to the pan-Bcl-2 family inhibitor, S1, 37,38 a Bcl-2 family inhibitor that binds to Mcl-1 and Bcl-2 with nanomolar affinity, disrupts Bax/Bcl-2 and Bak/Mcl-1 com.....
Document: As such, nilotinib is a promising candidate for Mcl-1-targeted cancer therapies. Cabergoline is an ergot derivative and a potent D2 dopamine receptor agonist used in the treatment of prolactinomas and uterine fibroids. 43 Cabergoline contains a tricyclic ring that is structurally related to the pan-Bcl-2 family inhibitor, S1, 37,38 a Bcl-2 family inhibitor that binds to Mcl-1 and Bcl-2 with nanomolar affinity, disrupts Bax/Bcl-2 and Bak/Mcl-1 complexes, induces Bax/Bak-dependent apoptosis, 37 increases oxidative stress, 44 and disrupts the interaction of Beclin 1 with Bcl-2. 45 Cabergoline is currently undergoing clinical trials in metastatic breast cancer as an adjuvant therapy of tamoxifen (ClinicalTrials.gov ID NCT01730729). Miltefosine is an alkylphosphocholine first studied as a treatment for cancer and approved for
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