Author: Moody, M. Anthony
Title: Modulation of HIV-1 immunity by adjuvants Document date: 2014_4_10
ID: 1nm1tbig_24
Snippet: Novel adjuvants continue to be studied in animal models. Lipid-based adjuvants like the AS0x series have been shown to stimulate strong antibody responses in guinea pigs, although responses were similar to those elicited by an oil-in-water emulsion adjuvant [68] . One of the adjuvants in this series, AS01B, elicited high-titered antibodies in rhesus macaques [69] and was also used in a human HIV-1 clinical trial wherein it generated antibody and .....
Document: Novel adjuvants continue to be studied in animal models. Lipid-based adjuvants like the AS0x series have been shown to stimulate strong antibody responses in guinea pigs, although responses were similar to those elicited by an oil-in-water emulsion adjuvant [68] . One of the adjuvants in this series, AS01B, elicited high-titered antibodies in rhesus macaques [69] and was also used in a human HIV-1 clinical trial wherein it generated antibody and T-cell responses [70] . Another adjuvant in that series, AS02A, also elicited immune responses in humans [71] , but which of the adjuvants in this series is the best for an HIV-1 vaccine is not yet established.
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